A General Overview of Viagra

There are different trade names of Viagra. In most of the countries it is sold under the name of Sildenafil. This is basically the medication which is prescribed by most of the physicians for the treatment of the problems related to pulmonary and arterial abnormalities. Moreover it is also prescribed for the persons who have a problem of erectile dysfunction. Mainly it is found to be effective in case of the pulmonary as well as arterial hypertension and other issues related to that. As far as the treatment of sexual dysfunction is concerned, it has been found that this medicine is not effective for females.

In most of the cases, the effectiveness of Viagra for men has been demonstrated in treatment of the erectile dysfunction.

Sildenafil
Side effects of Viagra

Commonly no side effects of Viagra have been reported at low doses. However at high doses or in case of prolonged usage of the medicine without any prescription may result in the symptoms of headaches along with heart burn. In many cases patients also report of the flushed skin.

  • This medicine is especially advised not to be taken by those people who are already the patient of cardiovascular diseases.
  • In addition to this, rarely people have reported the occurrence of prolonged erection which is a very serious side effect of this medicine. Prolonged erection in many cases causes damage to the penis.
  • This is sometimes accompanied by the sudden loss in hearing ability of the person. Sometimes this medicine may also contradict with other medicines as well being taken by the patients.
  • Therefore it is strictly prohibited to be used specifically by those patients who are taking nitrated in the form of nitro glycerin.
  • If taken in accompanied form with the nitrates medicine, Viagra can cause the drop in blood pressure to the dangerous levels which is obviously very much fatal.
Mode of action of Viagra

The mode of action of Viagra is ligand dependant type. It goes inside the cells and binds with the specific enzyme. The name of enzyme which is acted upon by Viagra is cGMP specific phosphodiestrase type 5. The medicine acts as an inhibitor of the enzyme by blocking its active site. In this way the genuine substrate of the enzyme which is cGMP cannot bind with the enzyme and hence it can also not be degraded. As a result the blood flow in the penis is regulated and it can be erected for a long time.

Discovery of Viagra and use as a medicine

Originally the medicine and its composition were discovered by Pfizer Company and its scientists. Since then it is being used in the medicines especially those concerned with erectile dysfunction, thereby causing the cure of problems which are leading to the sexual dysfunction. This medicine was made available in the market in 1998 and since then it has been the best known medicine for the treatment of erectile dysfunction. Other competitors of this medicine in the market are Tadalafil and Vardenafil.

 

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